An α2-adrenergic receptor agonist (α2-AR); reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats; neuronal depression can be reversed by the selective α2-AR antagonist RX781094 but not the α1-AR antagonists prazosin and WB-4101; acts as a muscle relaxant that inhibits α- and γ-rigidity in rats

Tizanidine (hydrochloride) – 500 mg

Brand:
Cayman
CAS:
64461-82-1
Storage:
-20
UN-No:
Non-Hazardous - /

Tizanidine is an α2-adrenergic receptor (α2-AR) agonist.{39278} Administration of tizanidine reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats. Tizanidine-induced neuronal depression is reversed by the selective α2-AR antagonist RX781094 but not the α1-AR antagonists prazosin (Item No. 15023) and WB-4101. It acts as a muscle relaxant that inhibits α- and γ-rigidity in rats, reflex muscle tone in rabbits, and the linguomadibular reflex in cats without sedative, hemodynamic, or neurochemical effects.{39279} Formulations containing tizanidine have been used for the treatment of stiff-person syndrome and to improve gait function in patients with incomplete spinal cord injuries.{39280,39281}  

 

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Description

An α2-adrenergic receptor agonist (α2-AR); reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats; neuronal depression can be reversed by the selective α2-AR antagonist RX781094 but not the α1-AR antagonists prazosin and WB-4101; acts as a muscle relaxant that inhibits α- and γ-rigidity in rats, reflex muscle tone in rabbits, and the linguomadibular reflex in cats ,

Formal name: 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine, monohydrochloride

Synonyms:  DS 103-282

Molecular weight: 290.2

CAS: 64461-82-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Pain Research

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