An alkaloid that irreversibly inhibits both human VMAT1 and VMAT2 (Ki = 34 and 12 nM

Reserpine – 5 g

Brand:
Cayman
CAS:
50-55-5
Storage:
-20
UN-No:
Non-Hazardous - 1544 / 6.1

Reserpine is an alkaloid isolated from dried roots of R. serpentine, which is used in traditional Indian medicine. Reserpine irreversibly inhibits both human isoforms of vesicular monoamine transporter, VMAT1 and VMAT2 (Kis = 34 and 12 nM, respectively).{26972,26973} As this leads to metabolism of monoamines, reserpine is used to experimentally deplete monoamines in animals.{26970,26971,20200} Reserpine also inhibits the multidrug resistance protein P-glycoprotein (IC50 = 0.5 µM).{25345}  

 

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Description

An alkaloid that irreversibly inhibits both human VMAT1 and VMAT2 (Ki = 34 and 12 nM, respectively); used to experimentally deplete monoamines in animals; also inhibits P-glycoprotein (IC50 = 0.5 µM)

Formal name: (3β,16β,17α,18β,20α)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester

Synonyms:  NSC 237659|NSC 59272|Rausedil

Molecular weight: 608.7

CAS: 50-55-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience

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