A CoA derivative used in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane; may mediate cancer cell cytotoxicity induced by fatty acid synthase inhibition

Malonyl Coenzyme A (lithium salt) – 10 mg

Brand:
Cayman
CAS:
108347-84-8
Storage:
-20
UN-No:
Non-Hazardous - /

Malonyl coenzyme A is a coenzyme A (CoA; Item No. 16147) derivative that is used in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane.{30631,30632} Malonyl-CoA is formed by acetyl-CoA carboxylase-mediated carboxylation of acetyl-CoA (Item No. 16160).{30631} Fatty acid synthase catalyzes the NADPH-dependent condensation of malonyl-CoA and acetyl-CoA to produce palmitate. Proliferating human cancer cells upregulate this fatty acid synthesis pathway as a strategy for survival. High levels of malonyl-CoA, achieved through fatty acid synthase inhibition, have been proposed to contribute to cancer cell apoptosis.{11993} Manlonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.{30632,30633}  

 

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Description

A CoA derivative used in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane; may mediate cancer cell cytotoxicity induced by fatty acid synthase inhibition

Formal name: S-(hydrogen propanedioate) coenzyme A, lithium salt

Synonyms:  Malonyl-CoA

Molecular weight: 860.5

CAS: 108347-84-8

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins

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