TXA2 receptor agonist; causes platelet shape change (EC50 ~6 nM) and aggregation (EC50 ~97 nM)

U-46619 – 5 mg

Brand:
Cayman
CAS:
56985-40-1
Storage:
-20
UN-No:
De Minimis - 1231 / 3

U-46619 is a stable analog of the endoperoxide prostaglandin H2, and a TP receptor agonist.{8322} It exhibits properties similar to thromboxane A2, causing platelet shape change and aggregation, and contraction of vascular smooth muscle.{490,714} Mean EC50 values for shape change in human, rat, and rabbit platelets are 4.8, 6.0, and 7.3 nM respectively, and for aggregation are 82, 145, and 65 nM, respectively.{1168}  

 

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Description

TXA2 receptor agonist; causes platelet shape change (EC50 ~6 nM) and aggregation (EC50 ~97 nM)

Formal name: 9,11-dideoxy-9α,11α-methanoepoxy-prosta-5Z,13E-dien-1-oic acid

Synonyms:  9,11-dideoxy-9α,11α-methanoepoxy PGF2α|9,11-dideoxy-9α,11α-methanoepoxy Prostaglandin F2α

Molecular weight: 350.5

CAS: 56985-40-1

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Vasculature||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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