A synthetic analog of fumagillin that inhibits angiogenesis; irreversibly inactivates methionine aminopeptidase-2 (IC50 = 2 µM)

TNP-470 – 10 mg

Brand:
Cayman
CAS:
129298-91-5
Storage:
-20
UN-No:
Non-Hazardous - /

TNP-470 is a synthetic analog of fumagillin (Item No. 11332) that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 µM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo.{26940,26939,13713} It is without effect on MetAP1.{26940} TNP-470 has therapeutic potential in cancer and microsporidiosis.{13713,26938}  

 

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Description

A synthetic analog of fumagillin that inhibits angiogenesis; irreversibly inactivates methionine aminopeptidase-2 (IC50 = 2 µM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo

Formal name: (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester N-(2-chloroacetyl)-carbamic acid

Synonyms:  AGM-1470|NSC 642492|O-(Chloroacetyl-carbamoyl) Fumagillol

Molecular weight: 401.9

CAS: 129298-91-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer|Angiogenesis||Research Area|Infectious Disease|Parasitic Diseases

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