An activator of p53; increases expression of p53 and the p53 target DR5 in wild-type and p53-knockout HCT116 colon adenocarcinoma cells; selective for p53

NSC 146109 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
59474-01-0
Storage:
-20
UN-No:
Non-Hazardous - /

NSC 146109 is an activator of the tumor suppressor p53 that increases expression of p53 and the p53 target DR5 in wild-type and p53-knockout HCT116 colon adenocarcinoma cells.{36574} It is selective for p53, having no effect on p73 expression in HCT116 cells at a concentration of 2 μM. NSC 146109 activates p53, which induces cell accumulation in the sub-G0/G1 phase and apoptosis in MCF-7 breast cancer cells.{36575} It increases p53 expression, decreases expression of the p53 suppressor MDMX, and reduces viability in a panel of breast cancer cell lines when used at a concentration of 0.5 μM. NSC 146109 also reduces growth of AMC-HN9 head and neck carcinoma (HNC) cells in vitro and in vivo when administered alone or in combination with cisplatin (Item No. 13119) in a mouse xenograft model at a dose of 70 mg/kg.{36576}  

 

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An activator of p53; increases expression of p53 and the p53 target DR5 in wild-type and p53-knockout HCT116 colon adenocarcinoma cells; selective for p53, having no effect on p73 expression in HCT116 cells (2 μM); increases p53 expression, decreases expression of the p53 suppressor MDMX, and reduces viability in a panel of breast cancer cell lines (0.5 μM); reduces growth of AMC-HN9 HNC cells in vitro and in vivo when administered alone or in combination with cisplatin in a mouse xenograft model (70 mg/kg)

Formal name: carbamimidothioic acid, (10-methyl-9-anthracenyl)methyl ester, monohydrochloride

Synonyms:  XI-011

Molecular weight: 316.8

CAS: 59474-01-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53

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