A selective

UNC3230 – 5 mg

Brand:
Cayman
CAS:
1031602-63-7
Storage:
-20
UN-No:
Non-Hazardous - /

Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG).{26548} Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2.{26548} UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM).{26548} It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases.{26548} At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.{26548}  

 

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Description

A selective, small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM); decreases PIP2 membrane levels in cultured DRG neurons by 45%, significantly reducing calcium signaling; displays antinociceptive effects in mouse models of chronic pain

Formal name: 5-[(cyclohexylcarbonyl)amino]-2-(phenylamino)-4-thiazolecarboxamide

Synonyms: 

Molecular weight: 344.4

CAS: 1031602-63-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Lipid Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Neuroscience|Pain Research

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