An alkaline aluminum−sucrose complex that inhibits peptic hydrolysis and raises gastric pH

Sucrose octasulfate (potassium salt) – 1 g

Brand:
Cayman
CAS:
73264-44-5
Storage:
-20
UN-No:
Non-Hazardous - /

Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum−sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.{26737} It can bind to exosite II of thrombin (KD = ~1.4 µM) and inhibit its catalytic activity (IC50 = 4.5 µM) and, as such, has been used as a surrogate for heparin.{26734} Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 µg/ml).{26736}  

 

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Description

An alkaline aluminum−sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury; inhibits thrombin activity (IC50 = 4.5 µM) and prevents FGF-2 binding to endothelial cells, inhibiting tumor growth in mouse melanoma and lung carcinoma models

Formal name: 2,3,4,6-tetrakis(hydrogen sulfate),1,3,4,6-tetra-O-sulfo-β-D-fructofuranosyl α-D-glucopyranoside, octapotassium salt

Synonyms:  SOS|Sucrosofate potassium

Molecular weight: 1,287.50

CAS: 73264-44-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Blood Coagulation Factors||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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