A GABAA receptor agonist whose potency varies depending on the receptor subunit composition (partial agonist at α1β2γ2 (ED50 = 143 µM)

Gaboxadol (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
85118-33-8
Storage:
-20
UN-No:
Non-Hazardous - /

Gaboxadol is a GABAA receptor agonist whose potency varies depending on the receptor subunit composition (partial agonist at α1β2γ2 (ED50 = 143 µM), full agonist at α5 (ED50 = 28-129 µM), and super agonist at α4β3δ (ED50 = 6 µM)).{26687} It also acts as an antagonist at ρ1 GABAC receptors (IC50 = 25 µM).{26687} Gaboxadol has been studied as a non-opioid analgesic and a novel hypnotic agent.{26813,26814,26812}  

 

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Description

A GABAA receptor agonist whose potency varies depending on the receptor subunit composition (partial agonist at α1β2γ2 (ED50 = 143 µM), full agonist at α5 (ED50 = 28-129 µM), and super agonist at α4β3δ (ED50 = 6 µM)); acts as an antagonist at ρ1 GABAC receptors (IC50 = 25 µM).

Formal name: 4,5,6,7-tetrahydro-isoxazolo[5,4-c]pyridin-3(2H)-one, monohydrochloride

Synonyms:  THIP

Molecular weight: 176.6

CAS: 85118-33-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Pain Research

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