A selective inhibitor of VEGFR2 (aka FLK1; IC50 = 700 nM)

SU 1498 – 5 mg

Brand:
Cayman
CAS:
168835-82-3
Storage:
-20
UN-No:
Non-Hazardous - /

SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.{26805,23658} It effectively blocks signaling through VEGFR2 both in vitro and in vivo.{26805,26806} SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.{26806,26802,26803,26804}  

 

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Description

A selective inhibitor of VEGFR2 (aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases; effectively blocks signaling through VEGFR2 both in vitro and in vivo

Formal name: (2E)-2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide

Synonyms:  AG-1498|Tyrphostin SU 1498

Molecular weight: 390.5

CAS: 168835-82-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Neuroscience|Ophthalmology

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