An isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids and the most frequently studied member of the isoprostane family

8-iso Prostaglandin F2α – 1 mg

Brand:
Cayman
CAS:
27415-26-5
Storage:
-20
UN-No:
Non-Hazardous - /

8-iso PGF2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.{320,371,855} It is present in human plasma in two distinct forms – esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine.{320,371} 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle.{6640} Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10−6 M) and I-BOP (3 x 10−7 M) with IC50 values of 1.6 x 10−6 M and 1.8 x 10−6 M, respectively.{855}  

 

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Description

An isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids and the most frequently studied member of the isoprostane family

Formal name: 9α,11α,15S-trihydroxy-(8β)-prosta-5Z,13E-dien-1-oic acid

Synonyms:  15-F2t-Isoprostane|8-epi PGF2α|8-iso-15(S)-Prostaglandin F2α|8-Isoprostane|iPF2α-III

Molecular weight: 354.5

CAS: 27415-26-5

Purity: ≥99%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Isoprostanes||Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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