Binds to β-catenin (Kd = 450 nM)

PNU 74654 – 1 mg

Brand:
Cayman
CAS:
113906-27-7
Storage:
-20
UN-No:
Non-Hazardous - /

The Wnt signaling pathway is integral to normal biological processes and inappropriately active in many cancers.{26669} PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway.{26667} Treatment of human adrenocortical cell lines with PNU 74654 significantly reduced expression of several Tcf/β-catenin target genes.{26670}  

 

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Description

Binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway

Formal name: 2-phenoxy-benzoic acid, 2-[(5-methyl-2-furanyl)methylene]hydrazide

Synonyms: 

Molecular weight: 320.3

CAS: 113906-27-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Signaling|Wnt Signaling||Research Area|Cell Biology|Cell Signaling|Wnt Signaling

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