A benzothiadiazide that acts as a potentiator of AMPA receptors

Cyclothiazide – 10 mg

Brand:
Cayman
CAS:
2259-96-3
Storage:
-20
UN-No:
Non-Hazardous - /

Receptors for AMPA are ionotropic glutamate receptors with critical roles in neurological development and function.{23037,21634,14541} Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC50 = 3.8 µM).{26686,26685,24138} It blocks the rapid agonist-induced desensitization of AMPA receptors, resulting in enhanced excitatory activity.{24138} Cyclothiazide is also a negative modulator of GABAA receptors, reversibly inhibiting both evoked and spontaneous inhibitory postsynaptic currents (IC50 = 58 µM).{26693,26687}  

 

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Description

A benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC50 = 3.8 µM); also a negative modulator of GABAA receptors, reversibly inhibiting both evoked and spontaneous inhibitory postsynaptic currents (IC50 = 58 µM)

Formal name: 1,​1-​dioxide 3-​bicyclo[2.2.1]​hept-​5-​en-​2-​yl-​6-​chloro-​3,​4-​dihydro-2H-​1,​2,​4-​benzothiadiazine-​7-​sulfonamide

Synonyms:  Doburil

Molecular weight: 389.9

CAS: 2259-96-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation||Research Area|Neuroscience

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