An alkaloid metabolite of nicotine as well as a major product of its pyrolysis; binds comparably to CYP2A6 and CYP2A13 (Kis = 7.5 and 5.6 µM

β-Nicotyrine – 5 mg

Brand:
Cayman
CAS:
487-19-4
Storage:
-20
UN-No:
De Minimis - 2810 / 6.1

β-Nicotyrine is an alkaloid metabolite of nicotine as well as a major product of its pyrolysis.{26726,26727} It binds comparably to two cytochrome P450 (CYP) isoforms, CYP2A6 and CYP2A13 (Kis = 7.5 and 5.6 µM, respectively), which are prominently involved in the metabolism of xenobiotics in the airways.{26724} However, β-nicotyrine appears to more effectively inactivate CYP2A6, leaving only 49% activity after a 10 minute exposure with 20 µM β-nicotyrine, as opposed to 87% remaining activity for CYP2A13 treated identically.{26722} Presumably through this effect, β-nicotyrine inhibits DNA strand breaks induced by the genotoxic tobacco metabolite (4-(methylnitrosamino)-1-(2-pyridyl)-1-butanone), which is bioactivated by CYP2A isoforms.{26723}  

 

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Description

An alkaloid metabolite of nicotine as well as a major product of its pyrolysis; binds comparably to CYP2A6 and CYP2A13 (Kis = 7.5 and 5.6 µM, respectively), but appears to more effectively inactivate CYP2A6

Formal name: 3-(1-methyl-1H-pyrrol-2-yl)-pyridine

Synonyms:  NSC 127943|NSC 407276|α-Nicotyrine

Molecular weight: 158.2

CAS: 487-19-4

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area

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