An inhibitor of the release of IL-17 by CD4 T cells stimulated with IL-15

Y320 – 1 mg

Brand:
Cayman
CAS:
288250-47-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

IL-15 is a pro-inflammatory cytokine with roles in cancer and autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, celiac disease, and alopecia areata.{28368} IL-15 can induce IL-17 production by CD4 T cells.{28367} Y320 is an inhibitor of the release of IL-17 by CD4 T cells stimulated with IL-15, either alone or in combination with CXCL12 and anti-CD3 monoclonal antibody (IC50s = 57.4 and 25.7 nM, respectively).{28367} Oral administration of Y320 (0.3-3 mg/kg) reduces the expression of inflammatory cytokines, including IL-17, and inhibits joint destruction in type II collagen-induced arthritis (CIA) in mice.{28367} In this model, it acts synergistically with TNF-α monoclonal antibody in ameliorating arthritis and joint destruction scores.{28367} Y320 also significantly reduces joint swelling in cynomolgus monkey CIA.{28367}  

 

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Description

An inhibitor of the release of IL-17 by CD4 T cells stimulated with IL-15, either alone or in combination with CXCL12 and anti-CD3 monoclonal antibody (IC50s = 57.4 and 25.7 nM, respectively); reduces the expression of inflammatory cytokines and inhibits joint destruction in collagen-induced arthritis in mice

Formal name: 1-​(4-​chlorophenyl)​-​N-​[3-​cyano-​4-​[4-​(4-​morpholinyl)​-​1-​piperidinyl]​phenyl]​-​5-​methyl-1H-​pyrazole-​4-​carboxamide

Synonyms: 

Molecular weight: 505

CAS: 288250-47-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis

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