An ATP-competitive inhibitor of Hsp90 that causes degradation of client proteins

XL888 – 10 mg

Brand:
Cayman
CAS:
1149705-71-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis.{18248} XL888 is an ATP-competitive inhibitor of Hsp90.{28107} Through this action, specific client proteins are degraded, resulting in cell cycle arrest or apoptosis.{28108,28110,28109} XL888 is orally bioavailable and shows efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice.{28107,28110}  

 

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Description

An ATP-competitive inhibitor of Hsp90 that causes degradation of client proteins, resulting in cell cycle arrest or apoptosis; orally bioavailable and shows efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice

Formal name: N1-[(3-endo)-8-[5-(cyclopropylcarbonyl)-2-pyridinyl]-8-azabicyclo[3.2.1]oct-3-yl]-2-methyl-5-[[(1R)-1-methylpropyl]amino]-1,4-benzenedicarboxamide

Synonyms: 

Molecular weight: 503.6

CAS: 1149705-71-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cellular Chaperones

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