A non-ATP competitive inhibitor of GSK3β (IC50 = 2 µM) that binds to the active site of GSK3β; used to study the role of GSK-3β during stem cell differentiation as well as in cell and animal models of Alzheimer’s disease and other neurodegenerative disorders

TDZD-8 – 1 mg

Brand:
Cayman
CAS:
327036-89-5
Storage:
-20
UN-No:
Non-Hazardous - /

TDZD-8 is a thiadiazolidine derivative that acts as a non-ATP competitive inhibitor of the serine/threonine kinase glycogen synthase kinase 3β (GSK3β; IC50 = 2 µM), binding to the active site of GSK3β.{27945} It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, cAMP-dependent protein kinase, or protein kinase C (IC50s = >100 µM).{27945} TDZD-8 has been used to study the role of GSK3β during stem cell differentiation as well as in cell and animal models of Alzheimer’s disease and other neurodegenerative disorders.{27946,27258}  

 

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Description

A non-ATP competitive inhibitor of GSK3β (IC50 = 2 µM) that binds to the active site of GSK3β; used to study the role of GSK-3β during stem cell differentiation as well as in cell and animal models of Alzheimer’s disease and other neurodegenerative disorders

Formal name: 2-​methyl-​4-​(phenylmethyl)​-1,​2,​4-​thiadiazolidine-​3,​5-​dione

Synonyms:  GSK3β Inhibitor I|NP 01139

Molecular weight: 222.3

CAS: 327036-89-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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