An ATP-competitive Pim-1 kinase inhibitor (IC50 = 50 nM) that displays selectivity over the related kinases

TCS PIM-1 1 – 50 mg

Brand:
Cayman
CAS:
491871-58-0
Storage:
-20
UN-No:
Non-Hazardous - /

The proto-oncogene serine/threonine-protein kinases, Pim-1 and Pim-2, are enzymes involved in cytokine signaling and participate in various signal transduction pathways, including cell growth, differentiation, and apoptosis. Their overexpression has been implicated in prostate cancer, some forms of leukemia, and lymphoma. TCS PIM-1 1 is an ATP-competitive Pim-1 kinase inhibitor (IC50 = 50 nM) that displays selectivity over the related kinases, Pim-2 and MEK1/2 (IC50s = >20 µM).{28246}  

 

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Description

An ATP-competitive Pim-1 kinase inhibitor (IC50 = 50 nM) that displays selectivity over the related kinases, Pim-2 and MEK1/2 (IC50s = >20 µM)

Formal name: 6-(5-bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-3-pyridinecarbonitrile

Synonyms:  Pim-1 Kinase Inhibitor II|SC-204330

Molecular weight: 367.2

CAS: 491871-58-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PIMs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling

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