An antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM) that is functional both in vitro and in vivo; also an agonist of GPR17 (EC50 values range from 7 nM to 6 µM

MDL 29951 – 1 mg

Brand:
Cayman
CAS:
130798-51-5
Storage:
-20
UN-No:
Non-Hazardous - /

NMDA receptors are neuroreceptors that have binding sites for glycine or D-serine as well as L-glutamate.{27735} MDL 29951 is an antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM).{27731} It is functional both in vitro and in vivo.{27731} MDL 29951 blocks NMDA receptor-dependent convulsions in audiogenic seizure-susceptible DBA/2J mice.{27731} It is used to evaluate the role of the glycine site of the NMDA receptor in neurological signaling.{27734,27733} MDL 29951 is also an agonist of the G protein-coupled receptor GPR17 (EC50 values range from 7 nM to 6 µM, depending on the assay).{27732} GPR17 is thought to be involved in oligodendrocyte differentiation and myelin formation/repair.{27732}  

 

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Description

An antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM) that is functional both in vitro and in vivo; also an agonist of GPR17 (EC50 values range from 7 nM to 6 µM, depending on the assay)

Formal name: 2-​carboxy-​4,​6-​dichloro-1H-​indole-​3-​propanoic acid

Synonyms: 

Molecular weight: 302.1

CAS: 130798-51-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Seizure Disorders

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