An inhibitor of the PARP domain of TNKS1 and TNKS2 (IC50s = 1.9 and 0.83 µM

JW 55 – 25 mg

Brand:
Cayman
CAS:
664993-53-7
Storage:
-20
UN-No:
Non-Hazardous - /

JW 55 is an inhibitor of the PARP domain of tankyrases (TNKS) 1 and 2 (IC50s = 1.9 and 0.83 µM, respectively).{32617} By inhibiting TNKS1/2, JW 55 stabilizes Axin2 and increases degradation of β-catenin, inhibiting the β-catenin signaling pathway (IC50 = 470 nM).{32617} It has been shown to decrease canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and to reduce proliferation of SW480 cells in vitro.{32617}  

 

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Description

An inhibitor of the PARP domain of TNKS1 and TNKS2 (IC50s = 1.9 and 0.83 µM, respectively); decreases canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and reduces proliferation of SW480 cells in vitro

Formal name: N-[4-[[[[tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide

Synonyms:  Tankyrase 1/2 Inhibitor IV

Molecular weight: 434.5

CAS: 664993-53-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Signaling|Wnt Signaling||Research Area|Cancer|DNA Damage and Repair|PARP||Research Area|Cell Biology|Cell Signaling|Wnt Signaling

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