An allosteric inhibitor of Bcr-Abl (IC50 = 267 nM); selective for Bcr-Abl over c-Abl and a panel of 63 additional kinases at 10 µM; inhibits proliferation of Ba/F3 cells (IC50 = 138 nM); reduces viral titers in IBV-infected Vero cells at 10 µM; inhibits LPS-induced production of NO and TNF-α in BV-2 microglia at 10 and 20 µM; reduces paw edema and increases the latency to paw withdrawal in a mouse model of inflammatory pain at 1 and 20 mg/kg; decreases mechanical and thermal hyperalgesia in a mouse model of STZ-induced diabetic neuropathy

GNF-2 – 1 mg

Brand:
Cayman
CAS:
778270-11-4
Storage:
-20
UN-No:
Non-Hazardous - /

GNF-2 is an allosteric inhibitor of Bcr-Abl (IC50 = 267 nM).{28970} It is selective for Bcr-Abl over c-Abl and a panel of 63 additional kinases at 10 µM. It inhibits proliferation of Ba/F3 cells (IC50 = 138 nM). GNF-2 (10 µM) reduces viral titers in Vero cells infected with infectious bronchitis virus (IBV), a coronavirus, via inhibition of IBV surface glycoprotein-induced syncytia formation and virus-cell fusion.{45828} It inhibits LPS-induced production of nitric oxide (NO) and TNF-α in BV-2 microglia when used at concentrations of 10 and 20 µM.{59702} GNF-2 (1 and 10 mg/kg) reduces paw edema and increases the latency to paw withdrawal in a mouse model of inflammatory pain induced by complete Freund’s adjuvant (CFA). It also decreases mechanical and thermal hyperalgesia in a mouse model of diabetic neuropathy induced by streptozotocin (STZ; Item No. 13104).  

 

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Description

An allosteric inhibitor of Bcr-Abl (IC50 = 267 nM); selective for Bcr-Abl over c-Abl and a panel of 63 additional kinases at 10 µM; inhibits proliferation of Ba/F3 cells (IC50 = 138 nM); reduces viral titers in IBV-infected Vero cells at 10 µM; inhibits LPS-induced production of NO and TNF-α in BV-2 microglia at 10 and 20 µM; reduces paw edema and increases the latency to paw withdrawal in a mouse model of inflammatory pain at 1 and 20 mg/kg; decreases mechanical and thermal hyperalgesia in a mouse model of STZ-induced diabetic neuropathy

Formal name: 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-benzamide

Synonyms:  Bcr-Abl Inhibitor

Molecular weight: 374.3

CAS: 778270-11-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Product Type|Biochemicals|Kinase Inhibitors|Abl Family & Bcr-Abl||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Abl family & Bcr-Abl Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Coronaviruses||Research Area|Neuroscience|Pain Research

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