A cell-permeable inhibitor of Arp2/3 complex action that inhibits actin polymerization in vitro

CK-636 – 5 mg

Brand:
Cayman
CAS:
442632-72-6
Storage:
-20
UN-No:
Non-Hazardous - /

Actin-related protein 3 (Arp3) heterodimerizes with Arp2 to form the Arp2/3 complex, which is involved in actin polymerization in a range of cell types. CK-636 is an inhibitor of Arp2/3 complex action that binds the complex and inhibits actin polymerization in vitro, using human, bovine and fission yeast proteins (IC50s = 4, 32, and 24 µM, respectively).{27974} It is cell permeable, as it prevents actin polymerization and the formation of actin filament comet tails by Listeria in infected SKOV3 cells (IC50 = 22 µM).{27974} CK-636 is used to explore the role of Arp2/3 complex in cellular functions, including epidermal barrier formation and T cell migration.{27975,27976}  

 

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Description

A cell-permeable inhibitor of Arp2/3 complex action that inhibits actin polymerization in vitro, using human, bovine and fission yeast proteins (IC50s = 4, 32, and 24 µM, respectively); prevents the formation of actin filament comet tails by Listeria in infected SKOV3 cells (IC50 = 22 µM)

Formal name: N-[2-(2-methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide

Synonyms: 

Molecular weight: 284.4

CAS: 442632-72-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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