A potent inhibitor of MEK5 (IC50 = 4.3 nM) and moderate inhibitor of ERK5 and TGFβR1 (IC50s = 810 and 1800 nM

BIX02188 – 5 mg

Brand:
Cayman
CAS:
334949-59-6
Storage:
-20
UN-No:
Non-Hazardous - /

BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGFβR1 (IC50s = 810 and 1,800 nM, respectively).{27914} It does not inhibit the closely related kinases MEK1, MEK2, ERK2, and JNK2 (IC50s = > 6,300 nM).{27914} BIX02188 inhibits phosphorylation of ERK5 in a dose-dependent manner without affecting phosphorylation of ERK1/2, p38 MAPK, or JNK1/2.{27914}  

 

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Description

A potent inhibitor of MEK5 (IC50 = 4.3 nM) and moderate inhibitor of ERK5 and TGFβR1 (IC50s = 810 and 1800 nM, respectively)

Formal name: (3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide

Synonyms: 

Molecular weight: 412.5

CAS: 334949-59-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling

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