An M1 muscarinic acetylcholine receptor antagonist (Ki = 0.59 nM in rat brain membranes); selective for M1 receptors over the serotonin transporter (Ki = 5

Benztropine (mesylate) – 1 g

Brand:
Cayman
CAS:
132-17-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Benztropine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 0.59 nM in rat brain membranes).{26585} It is selective for M1 receptors over the serotonin transporter (Ki = 5,150 nM), however, it also binds to the dopamine transporter and inhibits dopamine reuptake (Kis = 237 and 130 nM, respectively).{26585,20213,26584} Benztropine also inhibits acid sphingomyelinase by 87% when used at a concentration of 10 mM.{26583} Formulations containing benztropine have been used in the management of Parkinson’s disease symptoms such as involuntary tremor and dystonia.  

 

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Description

An M1 muscarinic acetylcholine receptor antagonist (Ki = 0.59 nM in rat brain membranes); selective for M1 receptors over the serotonin transporter (Ki = 5,150 nM); binds to the dopamine transporter and inhibits dopamine reuptake (Kis = 237 and 130 nM, respectively); inhibits acid sphingomyelinase by 87% at 10 mM

Formal name: (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane, monomethanesulfonate

Synonyms:  NSC 169913

Molecular weight: 403.5

CAS: 132-17-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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