A hydrophobic diterpene ester that rapidly induces cell death in proliferating keratinocytes through plasma membrane and mitochondrial disruption; causes inflammation due

Ingenol-3-angelate – 1 mg

Brand:
Cayman
CAS:
75567-37-2
Storage:
-20
UN-No:
Non-Hazardous - /

Ingenol-3-angelate is a hydrophobic diterpene ester that can be isolated from the euphorb E. peplus. It rapidly induces cell death in proliferating keratinocytes through plasma membrane and mitochondrial disruption, although it can also initiate apoptosis in some cancer cell lines (LD90 = ~190 µM).{26474} Secondarily, ingenol-3-angelate causes inflammation due, at least in part, to activation of PKC, leading to antibody-dependent cellular cytotoxicity.{26475,26472,23438} These actions have relevance in diminishing actinic keratosis and, possibly, other cancers of the skin.{21836,26473}  

 

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Description

A hydrophobic diterpene ester that rapidly induces cell death in proliferating keratinocytes through plasma membrane and mitochondrial disruption; causes inflammation due, at least in part, to activation of PKC, leading to antibody-dependent cellular cytotoxicity

Formal name: 2Z-methyl-2-butenoic acid, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester

Synonyms:  3-Ingenyl Angelate|Ingenol Mebutate|PEP005|Picato®

Molecular weight: 430.5

CAS: 75567-37-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Adaptive Immunity

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