A 2

Pyrintegrin – 10 mg

Brand:
Cayman
CAS:
1228445-38-2
Storage:
-20
UN-No:
Non-Hazardous - /

Human embryonic stem cells (hESC), unlike murine ESC, grow in vitro as large flattened two dimensional colonies.{23249} Dispersing these colonies, using trypsin to dissociate single hESC, results in massive cell death.{23249} Pyrintegrin is a 2,4-disubstituted pyrimidine that, at 2 µM, enhances the survival of hESC more than 30-fold after trypsin-mediated dissociation.{23249} It increases integrin-dependent attachment of hESC to extracellular matrices, including Matrigel™ and laminin, without significantly impacting cell proliferation.{23249} Pyrintegrin increases the binding of the activated β1 integrin-specific antibody HUTS-21 and enhances the phosphorylation of multiple growth factor receptors and their downstream kinases, PI3K and MAPK.{23249}  

 

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Description

A 2,4-disubstituted pyrimidine that, at 2 µM, enhances the survival of hESC more than 30-fold after trypsin-mediated dissociation; increases integrin-dependent attachment of hESC to extracellular matrices

Formal name: N-(cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]-benzenesulfonamide

Synonyms: 

Molecular weight: 451.5

CAS: 1228445-38-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Cell Biology|Stem Cell Research

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