A non-chlorinated analog of OTA that has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo

Ochratoxin B – 1 mg

Brand:
Cayman
CAS:
4825-86-9
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Ochratoxins are mycotoxins produced by Aspergillus and Penicillium species of fungi that contaminate foods.{20560,20493} Ochratoxin A (OTA, Item No. 11439) is a chlorinated form with toxicity that targets the kidneys, causing nephropathy and renal adenomas.{20560,20493} OTB is a non-chlorinated analog of OTA that has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion.{26426,26425,26424} OTB inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 µg/ml but lacks the genotoxic activity of OTA, even at higher concentrations.{26426}  

 

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Description

A non-chlorinated analog of OTA that has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion; inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 µg/ml but lacks the genotoxic activity of OTA

Formal name: N-[[(3R)-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine

Synonyms:  OTB

Molecular weight: 369.4

CAS: 4825-86-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Toxicology|Environmental|Agriculture

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