An inactive control to be used in experiments with AGK2; has IC50 values greater than 50 µM on SIRT1 and SIRT2 and greater than 5 µM on SIRT3

AGK7 – 1 mg

Brand:
Cayman
CAS:
304896-21-7
Storage:
-20
UN-No:
Non-Hazardous - /

AGK2 (Item No. 13145) is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.{17495,16624} AGK7 is an inactive control to be used in experiments with AGK2. It differs from AGK2, structurally, only in the position of nitrogen in the quinoline group.{17495} AGK7 has IC50 values greater than 50 µM on SIRT1 and SIRT2 and greater than 5 µM on SIRT3.{17495}  

 

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Description

An inactive control to be used in experiments with AGK2; has IC50 values greater than 50 µM on SIRT1 and SIRT2 and greater than 5 µM on SIRT3

Formal name: 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-8-quinolinyl-2-propenamide

Synonyms:  SIRT2 Inhibitor (Inactive Control)

Molecular weight: 434.3

CAS: 304896-21-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Neuroscience|Behavioral Neuroscience||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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