TTNPB – 10 mg

Brand:
Cayman
CAS:
71441-28-6
Storage:
-20
UN-No:
Non-Hazardous - /

TTNPB is an analog of retinoic acid (Item No. 11017) that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARα, RARβ, and RARγ, respectively).{27011,23075} It does not act on retinoid X receptors and weakly agonizes farnesoid X receptor (EC50 > 1 µM).{23075,12563} TTNPB is used to study RAR action in diverse processes, including epidermal cell proliferation, embryogenesis, and stem cell differentiation.{27013,27012,25645,27014}  

 

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Description

An analog of retinoic acid that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARα, RARβ, and RARγ, respectively); used to study RAR action in epidermal cell proliferation, embryogenesis, and stem cell differentiation


Formal name: 4-[(1E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propen-1-yl]-benzoic acid

Synonyms:  AGN 191183|Arotinoid Acid|Ro 13-7410

Molecular weight: 348.5

CAS: 71441-28-6

Purity: ≥98%

Formulation: A crystalline solid


Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cell Biology|Stem Cell Research|Differentiation