A natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis; activates histamine release

Sinomenine (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
6080-33-7
Storage:
-20
UN-No:
Non-Hazardous - /

Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis.{26557} It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events.{26557,26555,26556,26558} Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain.{26556,26557} It enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-glycoprotein.{26559,26554}  

 

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Description

A natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis; activates histamine release, reduces joint stiffness and pain, and alters cytokine generation; impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain

Formal name: (9a,13a,14a)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-one, monohydrochloride

Synonyms:  Cucoline|NSC 76021

Molecular weight: 365.9

CAS: 6080-33-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Immunosuppressants||Research Area|Neuroscience|Pain Research

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