An intermediate in the synthesis of the plant hormone ethylene; acts as a partial agonist at the glycine-binding site on NMDA receptors (EC50 = 0.7-0.9 µM) and

1-Aminocyclopropanecarboxylic Acid – 1 g

Brand:
Cayman
CAS:
22059-21-8
Storage:
-20
UN-No:
Non-Hazardous - /

1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence.{26310} ACPC has been shown to modulate NMDA receptor activity by acting as a partial agonist at the glycine-binding site on NMDA receptors (EC50 = 0.7-0.9 µM) in the presence of low levels (1 µM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 µM) of glutamate.{26311} This compound has been reported to protect against neuron cell death in in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity.{26311}  

 

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Description

An intermediate in the synthesis of the plant hormone ethylene; acts as a partial agonist at the glycine-binding site on NMDA receptors (EC50 = 0.7-0.9 µM) and, in the presence of high levels of glutamate, as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM); protects against neuron cell death in in vivo models of ischemia

Formal name: 1-amino-cyclopropanecarboxylic acid

Synonyms:  ACC|ACPC|NSC 98430

Molecular weight: 101.1

CAS: 22059-21-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Plant Biology|Plant Growth Regulators

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