An endogenous thyroxine metabolite that activates the trace amine-associated receptor 1 at nanomolar concentrations; influences thyroid hormone actions including body temperature

3-Iodothyronamine (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
788824-64-6
Storage:
-20
UN-No:
De Minimis - 3077 / 9

3-Iodothyronamine is derived from the deiodination and decarboxylation of endogenous thyroxine. It activates the G protein-coupled receptor known as trace amine-associated receptor 1 at nanomolar concentrations whereupon it rapidly influences thyroid hormone actions including body temperature, heart rate, and cardiac output.{22581,26261} It has also been reported to function in controlling lipid and glucose utilization, hormonal secretion, and neuronal function, and has been considered for use in chemically-induced hibernation for medical purposes.{26262,26264,26263}  

 

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Description

An endogenous thyroxine metabolite that activates the trace amine-associated receptor 1 at nanomolar concentrations; influences thyroid hormone actions including body temperature, heart rate, and cardiac output as well as balances lipid and glucose utilization

Formal name: 4-[4-(2-aminoethyl)-2-iodophenoxy]-phenol, monohydrochloride

Synonyms:  T1AM

Molecular weight: 391.6

CAS: 788824-64-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Heart||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones||Research Area|Neuroscience|Neuroendocrinology

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