A cell-permeable

Boc-D-FMK – 1 mg

Brand:
Cayman
CAS:
187389-53-3
Storage:
-20
UN-No:
Non-Hazardous - /

Boc-D-FMK is a cell-permeable, irreversible pan-caspase inhibitor.{26387,26384} Also known as Boc-D(OMe)-FMK, this compound contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Boc-D-FMK blocks apoptosis stimulated by TNF-α in neutrophils (IC50 = 39 µM), by bile duct ligation in hepatocytes, and by TNF-α in renal endothelial cells.{26383,26385,26386} The FMK pharmacophore is known to interact with non-caspase cysteine proteases, presumably explaining why Boc-D-FMK also inhibits cathepsins H and L.{26387}  

 

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Description

A cell-permeable, irreversible pan-caspase inhibitor; contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor

Formal name: 3S-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid, methyl ester

Synonyms:  BAF|Boc-Asp(OMe)-FMK|Boc-D(OMe)-FMK|Boc-D-Fluoromethyl Ketone

Molecular weight: 263.3

CAS: 187389-53-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Caspases||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Pyroptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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