A thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 µM); dose-dependently increases the level of retromer proteins

TPT-260 (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
2076-91-7
Storage:
-20
UN-No:
Non-Hazardous - /

Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 µM).{25946} In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.{25946}  

 

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Description

A thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 µM); dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP in cultured hippocampal neurons

Formal name: carbamimidothioic acid, C,C’-[2,5-thiophenediylbis(methylene)] ester, dihydrochloride

Synonyms:  NSC 55712|R55

Molecular weight: 333.3

CAS: 2076-91-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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