A nucleoside analog and prodrug form of ara-CTP; triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase

Cytarabine – 10 g

Brand:
Cayman
CAS:
147-94-4
Storage:
-20
UN-No:
Non-Hazardous - /

Cytarabine (ara-C) is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP.{48724} It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase.{48725} Ara-C inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human leukemia cell lines with IC50 values of 37, 17, 16, and 72 nM, respectively.{48726} It induces cell cycle arrest at the G0/G1 phase in HL-60 cells when used at concentrations of 2.5 and 15 µM.{48724} ara-C (75 mg/kg per day, i.p.) reduces tumor growth and increases tumor caspase-3 activity in an MOLM-13 mouse xenograft model.{48727} It also increases survival and reduces brain herpesvirus titers in infected rats when administered subcutaneously at doses of 80 and 320 mg/kg.{48728} Formulations containing ara-C have been used in the treatment of acute myeloid leukemia.  

 

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Description

A nucleoside analog and prodrug form of ara-CTP; triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase; inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human leukemia cell lines (IC50s = 37, 17, 16, and 72 nM, respectively); induces cell cycle arrest at the G0/G1 phase in HL-60 cells at 2.5 and 15 µM; reduces tumor growth and increases tumor caspase-3 activity in an MOLM-13 mouse xenograft model at 75 mg/kg per day intraperitoneally; increases survival and reduces brain herpesvirus titers in infected rats at 80 and 320 mg/kg subcutaneously

Formal name: 4-amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone

Synonyms:  1-β-D-Arabinofuranosylcytosine|NSC 287459|NSC 63878|U-19920A

Molecular weight: 243.2

CAS: 147-94-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HSV

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