An iron chelator

Ciclopirox – 500 mg

Brand:
Cayman
CAS:
29342-05-0
Storage:
22
UN-No:
Non-Hazardous - /

Ciclopirox is an iron chelator, antifungal, and anticancer agent.{26941,41490,53131,53132} It inhibits the iron-dependent enzyme prolyl hydroxylase 2 (PHD2; IC50 = 1.58 μM), an effect that is reduced in the presence of iron.{26941} It stabilizes hypoxia-inducible factor-α (HIF-1α) under normoxic conditions in rat glomus cells when used at a concentration of 5 μM.{33213} Ciclopirox is active against clinical isolates of T. rubrum, T. mentagrophytes, and C. albicans (MICs = 0.03-0.5, 0.03-0.5, and 0.06-0.5 μg/ml, respectively) and inhibits growth of T. mentagrophytes on porcine skin ex vivo when applied topically.{41490,53131} It inhibits proliferation of Rh30, HT-29, and MDA-MB-231 cells in a concentration-dependent manner and halts the cell cycle at the G1/G0 phase and induces apoptosis in Rh30 cells.{53132} Ciclopirox (25 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model. Formulations containing ciclopirox have been used in the topical treatment of fungal infections.  

 

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Description

An iron chelator, antifungal, and anticancer agent; inhibits PHD2 (IC50 = 1.58 μM), an effect that is reduced in the presence of iron; stabilizes HIF-1α under normoxic conditions in rat glomus cells at 5 μM; active against clinical isolates of T. rubrum, T. mentagrophytes, and C. albicans (MICs = 0.03-0.5, 0.03-0.5, and 0.06-0.5 μg/ml, respectively) and inhibits growth of T. mentagrophytes on porcine skin ex vivo when applied topically; inhibits proliferation of Rh30, HT-29, and MDA-MB-231 cells in a concentration-dependent manner; halts the cell cycle at the G1/G0 phase and induces apoptosis in Rh30 cells; reduces tumor growth in an MDA-MB-231 mouse xenograft model at 25 mg/kg

Formal name: 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone

Synonyms:  HOE 296b

Molecular weight: 207.3

CAS: 29342-05-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Metal Chelators||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Transcription Factors|HIF-1α||Research Area|Cancer|Tumor Microenvironment||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Infectious Disease|Fungal Diseases|Ringworm

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