A protease inhibitor; inhibits trypsin (Ki = 1 nM)

Camostat (mesylate) – 5 mg

Brand:
Cayman
CAS:
59721-29-8
Storage:
-20
UN-No:
Non-Hazardous - /

Camostat is a protease inhibitor.{26053,26054} It inhibits trypsin (Ki = 1 nM), as well as various inflammatory proteases, including plasmin, kallikrein, and thrombin. Camostat (50 µM) inhibits entry of vesicular stomatitis virus (VSV) particles pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 surface glycoprotein in Calu-3 cells and primary human lung epithelial cells.{49542} It reduces the number of SARS-CoV-2 genomic equivalents, a marker of infection, in Calu-3 cells. Camostat inhibits sodium channel function in human airway epithelial cells (IC50 = 50 nM) and enhances mucociliary clearance in sheep.{26503} Dietary administration of camostat (1 mg/kg) inhibits the production of TNF-α and chemokine (C-C motif) ligand 2 (CCL2) by monocytes, as well as proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.{26054}  

 

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Description

A protease inhibitor; inhibits trypsin (Ki = 1 nM), as well as various inflammatory proteases, including plasmin, kallikrein, and thrombin; inhibits entry of VSV particles pseudotyped with SARS-CoV or SARS-CoV-2 surface glycoprotein in Calu-3 cells and primary human lung epithelial cells at 50 µM; reduces the number of SARS-CoV-2 genomic equivalents, a marker of infection, in Calu-3 cells; inhibits sodium channel function in human airway epithelial cells (IC50 = 50 nM); enhances mucociliary clearance in sheep; dietary administration inhibits the production of TNF-α and chemokine (C-C motif) ligand 2 (CCL2) by monocytes, as well as proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis at 1 mg/kg

Formal name: 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic acid, 2-(dimethylamino)-2-oxoethyl ester, monomethanesulfonate

Synonyms:  Foipan|FOY 305

Molecular weight: 494.5

CAS: 59721-29-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Product Type|Biochemicals|Antivirals|Protease Inhibitors||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|COVID-19||Research Area|Infectious Disease|Viral Diseases|Coronaviruses

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