A long-acting β2-AR agonist (EC50s = 0.79

Salmeterol (xinafoate) – 100 mg

Brand:
Cayman
CAS:
94749-08-3
Storage:
-20
UN-No:
Non-Hazardous - /

Salmeterol is a long-acting β2-adrenergic receptor agonist (β2-AR; EC50s = 0.79, 63.1, and 9.4 nM for β2-, β1-, and β3-ARs, respectively).{25442} It inhibits electrically-stimulated contraction of isolated guinea pig trachea strips (EC50 = 2.51 nM) and histamine-induced bronchoconstriction in guinea pigs via aerosol administration of doses ranging from 0.12 to 12 mM.{25442,42567} Salmeterol binds to an exosite domain of β2-adrenergic receptors, producing a slow onset of action and prolonged activation.{25994} Formulations containing salmeterol have been used in the treatment of asthma, including exercise-induced asthma, and chronic obstructive pulmonary disease.  

 

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Description

A long-acting β2-AR agonist (EC50s = 0.79, 63.1, and 9.4 nM for β2-, β1-, and β3-ARs, respectively); inhibits electrically-stimulated contraction of isolated guinea pig trachea strips (EC50 = 2.51 nM); inhibits histamine-induced bronchoconstriction in guinea pigs via aerosol administration at 0.12-12 mM

Formal name: 4-hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol, 1-hydroxy-2-naphthalenecarboxylic acid

Synonyms:  GR-33343G

Molecular weight: 603.8

CAS: 94749-08-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Immunology & Inflammation|Pulmonary Diseases|COPD/Emphysema

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