A lysosomal condensation product that selectively eliminates dipeptidyl peptidase I-expressing immune cells

L-Leucyl-L-Leucine methyl ester (hydrochloride) – 1 g

Brand:
Cayman
CAS:
6491-83-4
Storage:
-20
UN-No:
Non-Hazardous - /

L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells.{26052,26051} It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells.{26051} Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells.{26051}  

 

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Description

A lysosomal condensation product that selectively eliminates dipeptidyl peptidase I-expressing immune cells, including cytotoxic T cells and natural killer cells

Formal name: L-leucyl-L-leucine, methyl ester, monohydrochloride

Synonyms:  LLME|LLOMe

Molecular weight: 294.8

CAS: 6491-83-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity

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