Selectively inhibits human NHE-1 with an IC50 value of 14 nM; reduces infarct size in a rabbit myocardial ischemia-reperfusion model without adversely affecting hemodynamics or cardiac function

Zoniporide (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
241800-97-5
Storage:
-20
UN-No:
Non-Hazardous - /

The sodium-hydrogen exchanger isoform-1 (NHE-1) is the most predominant isoform of the Na+/H+ exchanger and is expressed in the heart where it contributes to cardiomyocyte pH homeostasis.{22706} It plays an important role in the myocardial response to ischemia-reperfusion. Zoniporide inhibits human NHE-1 with an IC50 value of 14 nM, displaying greater than 150-fold selectivity over other NHE isoforms.{25880} It has been shown to reduce infarct size in a rabbit myocardial ischemia-reperfusion model without adversely affecting hemodynamics or cardiac function.{22706} In isolated heart, zoniporide reduced infarct size with an EC50 value of 0.25 nM.{25880}  

 

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Description

Selectively inhibits human NHE-1 with an IC50 value of 14 nM; reduces infarct size in a rabbit myocardial ischemia-reperfusion model without adversely affecting hemodynamics or cardiac function

Formal name: N-(aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide, monohydrochloride

Synonyms:  CP 597,396

Molecular weight: 356.8

CAS: 241800-97-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction

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