A cell-permeable cAMP analog with improved lipophilicity compared to the PKA activators

Sp-8-bromo-Cyclic AMPS (sodium salt) – 1 mg

Brand:
Cayman
CAS:
1573115-90-8
Storage:
-20
UN-No:
Non-Hazardous - /

Sp-8-bromo-cyclic AMPS (Sp-8-bromo-cAMPS) is a cell-permeable, cAMP analog that combines an exocyclic sulfur substitution in the axial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.{26218,26215} This configuration pools the structural features of two established cyclic-AMP-dependent protein kinase (PKA) activators, 8-bromo-cAMP (Item No. 14431) and Sp-cAMPS (Item No. 14983). Sp-8-bromo-cAMPS is a PKA agonist (EC50 = 1.5 µM) with improved lipophilicity and is not readily degraded by cyclic nucleotide phosphodiesterases.{26217,26216}  

 

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Description

A cell-permeable cAMP analog with improved lipophilicity compared to the PKA activators, 8-bromo-cAMP and Sp-cyclic AMPS; not readily degraded by PDE

Formal name: (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-sulfide, monosodium salt

Synonyms:  8-Bromoadenosine 3′,5′-cyclic Monophosphothioate SP-Isomer|Sp-8-bromo-cAMPS

Molecular weight: 446.2

CAS: 1573115-90-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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