A melatonin receptor antagonist that preferentially targets MT1B over MT1A (Ki values = 10-27 and 158-513 nM

Luzindole – 5 mg

Brand:
Cayman
CAS:
117946-91-5
Storage:
-20
UN-No:
Non-Hazardous - /

In addition to intrinsic antioxidant activities, melatonin (Item No. 14427) evokes its effects through the G protein-coupled receptors MT1A (MT1) and MT1B (MT2).{26016} Luzindole is a melatonin receptor antagonist that preferentially targets MT1B over MT1A (Ki values are = 10-27 and 158-513 nM, respectively).{26020,26015,26017} Luzindole is used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways, including circadian rhythms, animal behavior, and melanophore response.{26018,26019,26020}  

 

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Description

A melatonin receptor antagonist that preferentially targets MT1B over MT1A (Ki values = 10-27 and 158-513 nM, respectively); used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways

Formal name: N-[2-[2-(phenylmethyl)-1H-indol-3-yl]ethyl]-acetamide

Synonyms:  N-0774

Molecular weight: 292.3

CAS: 117946-91-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms

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