An inhibitor of steroid 5α-reductase types I and II (Kis = 6 and 7 nM

Dutasteride – 5 mg

Brand:
Cayman
CAS:
164656-23-9
Storage:
-20
UN-No:
Non-Hazardous - /

Dutasteride is a dual inhibitor of 5α-reductase types I and II (Kis = 6 and 7 nM, respectively).{25831,25832,43107} Its inhibition is time-dependent inhibitor with apparent Ki values of 17 and 4.3 nM at 10- and 30-minute reaction times, respectively.{25831} Dutasteride decreases prostate weight in a rat model of benign prostatic hypertrophy induced by testosterone after castration when administered daily for 28 days at doses of 0.045 mg/kg as a solution or 0.756 mg/kg in subcutaneous microspheres.{43105} It also decreases prostate weight in large probasin-large T antigen mice, a transgenic model of prostate cancer.{43106} Formulations containing dutasteride have been used in the treatment of benign prostatic hyperplasia.  

 

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Description

An inhibitor of steroid 5α-reductase types I and II (Kis = 6 and 7 nM, respectively); a time-dependent inhibitor with apparent Ki values of 17 and 4.3 nM at 10- and 30-minute reaction times, respectively; decreases prostate weight in a rat model of benign prostatic hypertrophy induced by testosterone at 0.045 and 0.756 mg/kg administered as a solution or in subcutaneous microspheres, respectively, daily for 28 days; also decreases prostate weight in a transgenic model of prostate cancer

Formal name: N-[2,5-bis(trifluoromethyl)phenyl]-2,4aR,4bS,5,6,6aS,7S,8,9,9aS,9bS,10,11,11aR-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide

Synonyms: 

Molecular weight: 528.5

CAS: 164656-23-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Reproductive Biology

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