A potent antagonist of the PAF receptor

CV-6209 (chloride) – 1 mg

Brand:
Cayman
CAS:
100488-87-7
Storage:
-20
UN-No:
Non-Hazardous - /

CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively.{27971} It has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen.{27971} CV-6209 is bioavailable, as it prevents PAF-induced hypotension in rats, while not blocking hypotension triggered by arachidonic acid (Item No. 90010), histamine, bradykinin (Item No. 15539), or isoproterenol (Item No. 15592).{27971} CV-6209 is used to study the role of PAF receptor signaling in vitro and in vivo.{27973,27972}  

 

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Description

A potent antagonist of the PAF receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively; prevents PAF-induced hypotension in rats, while not blocking hypotension triggered by arachidonic acid, histamine, bradykinin, or isoproterenol

Formal name: 2-(2-acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-pyridinium, monochloride

Synonyms: 

Molecular weight: 642.3

CAS: 100488-87-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypotension

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