An analog of dapagliflozin that displays similar selectivity for inhibiting SGLT2 over SGLT1 (Kis = 5.3 and 330 nM

fluoro-Dapagliflozin – 5 mg

Brand:
Cayman
CAS:
1181681-43-5
Storage:
-20
UN-No:
Non-Hazardous - /

Dapagliflozin (Item No. 11573) is a selective sodium-glucose cotransporter (SGLT) inhibitor that blocks glucose transport with about 100-fold selectivity for SGLT2 (Ki = 6 nM; EC50 = 1.1 nM) over SGLT1 (Ki = 390 nM).{20895,20896} It improves glucose tolerance in normal rats and reduces hyperglycemia in Zucker diabetic fatty rats.{22762} fluoro-Dapagliflozin is an analog of dapagliflozin that displays similar selectivity for inhibiting SGLT2 over SGLT1 (Kis = 5.3 and 330 nM, respectively).{20895} fluoro-Dapagliflozin (10 nM) significantly reduces phlorizin-sensitive sugar transport in COS-1 cells expressing human SGLT2.{20895}  

 

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Description

An analog of dapagliflozin that displays similar selectivity for inhibiting SGLT2 over SGLT1 (Kis = 5.3 and 330 nM, respectively); significantly reduces phlorizin-sensitive sugar transport in COS-1 cells expressing human SGLT2

Formal name: (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-4-deoxy-4-fluoro-D-glucitol

Synonyms:  flouro-DAPA

Molecular weight: 410.9

CAS: 1181681-43-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area

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