A selective inhibitor of TGF-β and activin signaling that suppresses SMAD3 phosphorylation (IC50 = 3 µM); reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts

SMAD3 Inhibitor, SIS3 – 5 mg

Brand:
Cayman
CAS:
1009104-85-1
Storage:
-20
UN-No:
Non-Hazardous - /

SMAD3 is a receptor-regulated intracellular protein that functions downstream of TGF-β and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix. SMAD3 Inhibitor, SIS3 selectively inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation (IC50 = 3 µM) without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways.{25955} It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.{25955}  

 

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Description

A selective inhibitor of TGF-β and activin signaling that suppresses SMAD3 phosphorylation (IC50 = 3 µM); reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts

Formal name: 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-propen-1-one

Synonyms: 

Molecular weight: 453.5

CAS: 1009104-85-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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