A cell-permeable inhibitor of the dimerization of c-Myc and Max at 64 µM

10058-F4 – 50 mg

Brand:
Cayman
CAS:
403811-55-2
Storage:
-20
UN-No:
Non-Hazardous - /

The Myc proto-oncogenes interact with Max to form a dimer that regulates gene transcription. The protein c-Myc, in particular, promotes gene expression relevant to cell growth and thus drives cancer. 10058-F4 is a cell-permeable thiazolidinone that inhibits the dimerization of c-Myc and Max at 64 µM, preventing c-Myc-dependent gene expression and cell proliferation.{25765} It induces cell cycle arrest, apoptosis, and myeloid differentiation at 100 µM in human acute myeloid leukemia cells.{25762} 10058-F4 is rapidly metabolized in mice when given intravenously, limiting its effects on tumors in vivo.{25761} In addition to c-Myc, 10058-F4 inhibits the nuclear Myc protein, N-Myc, at 50 µM, inducing arrest, apoptosis, and differentiation in neuroblastoma cells overexpressing the gene for N-Myc.{25763} This compound can be used to delineate novel actions of Myc proteins, especially those related to lipid and glucose metabolism.{25763,25764}  

 

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Description

A cell-permeable inhibitor of the dimerization of c-Myc and Max at 64 µM, preventing c-Myc-dependent gene expression and cell proliferation; induces cell cycle arrest, apoptosis, and myeloid differentiation at 100 µM in human acute myeloid leukemia cells; inhibits the nuclear Myc protein, N-Myc, at 50 µM

Formal name: 5-[(4-ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

Synonyms: 

Molecular weight: 249.4

CAS: 403811-55-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Transcription Factors

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