A potent MAO inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM

Clorgyline (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
17780-75-5
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM, respectively).{25815,25817} This inhibition is irreversible.{25815} Clorgyline is without effect on serotonin (Item No. 14332) receptors, but it does inhibit the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM).{25805,25816} As MAO-A preferentially oxidizes serotonin, selective MAO-A inhibitors have applications in ameliorating depression and anxiety.{25815,23884}  

 

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Description

A potent MAO inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM, respectively); also inhibits the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM)

Formal name: N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propyn-1-amine, monohydrochloride

Synonyms:  N-2,4-Dichlorophenoxypropyl-N-methylpropargylamine

Molecular weight: 308.6

CAS: 17780-75-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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