A selective small molecule inhibitor of PKD (IC50s = 182

CID755673 – 10 mg

Brand:
Cayman
CAS:
521937-07-5
Storage:
-20
UN-No:
Non-Hazardous - /

Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.{13335} The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CID755673 is a small molecule inhibitor of PKD (IC50s = 182, 280, 227 nM for PKD1, 2, and 3, respectively) that exhibits higher selectivity for PKD over Akt, polo-like kinase 1, CDK activating kinase, CAMKII and three different PKC isoforms (IC50s range from 15 to > 50 µM).{25787} At 25 µM, CID755673 has been shown to inhibit prostate cancer cell proliferation, cell migration, and invasion.{25787}  

 

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Description

A selective small molecule inhibitor of PKD (IC50s = 182, 280, 227 nM for PKD1, 2, and 3, respectively); 25 µM has been shown to inhibit prostate cancer cell proliferation, cell migration, and invasion

Formal name: 2,3,4,5-tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one

Synonyms: 

Molecular weight: 217.2

CAS: 521937-07-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKD & PKG||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|PKD Signaling

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