A tricyclic antidepressant that blocks norepinephrine and serotonin transporters (KDs = 4.4 and 18 nM

Nortriptyline (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
894-71-3
Storage:
-20
UN-No:
Non-Hazardous - /

Nortriptyline is a tricyclic antidepressant that blocks norepinephrine and serotonin (Item No. 14332) transporters (KDs = 4.4 and 18 nM, respectively) more potently than the dopamine transporter (KD = 1.1 µM).{22877} It also antagonizes serotonin, histamine, muscarinic, and α-adrenergic receptors (Kis = 5.0, 8.5, 10, 40, and 60 nM for 5-HT2A, 5-HT2C, H1, α1, and M1 receptors, respectively).{25805,25914,25806,25803}  

 

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Description

A tricyclic antidepressant that blocks norepinephrine and serotonin transporters (KDs = 4.4 and 18 nM, respectively) more potently than the dopamine transporter (KD = 1.1 µM)

Formal name: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, monohydrochloride

Synonyms:  Acetexa

Molecular weight: 299.8

CAS: 894-71-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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